Articles from IAVI

Initial award funds process development, manufacturing, and clinical evaluation of a single-dose vaccine candidate through strategic partnerships with Hilleman Laboratories, SK bioscience, and IDT Biologika

IAVI, a nonprofit scientific research organization, announces that volunteers at the PREVAIL clinical trial site at Redemption Hospital (RH1) in Monrovia, Liberia, have been vaccinated with IAVI’s novel vaccine candidate against Lassa fever virus (LASV) in a Phase I clinical trial, named IAVI C102, supported by the Coalition for Epidemic Preparedness Innovations (CEPI).

IAVI, a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges, is very pleased to announce the appointment of Marion F. Gruber, Ph.D., M.S., as Vice President, Public Health and Regulatory Science.

IAVI announced today the award of up to US$126 million from the Biomedical Advanced Research and Development Authority (BARDA) at the U.S. Department of Health and Human Services to develop two recombinant vesicular stomatitis virus (rVSV)-vectored filovirus vaccine candidates. This award supports preclinical activities and includes options for clinical development up to and inclusive of a Phase II clinical trial of IAVI’s rVSV Sudan ebolavirus vaccine candidate (rVSVΔG-SUDV-GP). Optional work that would continue the development of IAVI’s Marburg virus vaccine candidate (rVSVΔG-MARV-GP) that is currently supported by the Defense Threat Reduction Agency of the U.S. Department of Defense could be funded at a later date.

Spanish biopharmaceutical company Biofabri and IAVI, an international nonprofit research organization focused on developing vaccines and antibodies against infectious and neglected diseases, today announced their intention to partner on efficacy trials of the tuberculosis (TB) vaccine candidate MTBVAC.

IAVI has received an award of €22.8 million from the European & Developing Countries Clinical Trials Partnership (EDCTP) and the Coalition for Epidemic Preparedness Innovations (CEPI) to conduct a Phase IIb clinical trial of a novel vaccine candidate to prevent Lassa fever disease. An acute viral illness endemic to many parts of West Africa, Lassa fever causes significant annual outbreaks of disease. There are an estimated 300,000 to 500,000 cases and 5,000 related deaths each year1. Despite this disease burden, which is believed to be significantly underestimated, no vaccine for Lassa fever is currently available.